Murine Anti-vaccinia Virus D8 Antibodies Target Different Epitopes and Differ in Their Ability to Block D8 Binding to CS-E
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منابع مشابه
Murine Anti-vaccinia Virus D8 Antibodies Target Different Epitopes and Differ in Their Ability to Block D8 Binding to CS-E
The IMV envelope protein D8 is an adhesion molecule and a major immunodominant antigen of vaccinia virus (VACV). Here we identified the optimal D8 ligand to be chondroitin sulfate E (CS-E). CS-E is characterized by a disaccharide moiety with two sulfated hydroxyl groups at positions 4' and 6' of GalNAc. To study the role of antibodies in preventing D8 adhesion to CS-E, we have used a panel of m...
متن کاملStructure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.
Vaccinia virus (VACV) envelope protein D8 is one of three glycosaminoglycan adhesion molecules and binds to the linear polysaccharide chondroitin sulfate (CS). D8 is also a target for neutralizing antibody responses that are elicited by the smallpox vaccine, which has enabled the first eradication of a human viral pathogen and is a useful model for studying antibody responses. However, to date,...
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We address a few subtle issues regarding the interacting D0-D8 system. There are two existing interpretations for the counter-intuitive non-vanishing attractive cylinder-diagram R-R potential. We improve them each by properly dealing with the divergence of potential in the R-R as well as the NS-NS sector, which has been ignored so far. We further test them by considering the D8 to carry a flux,...
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Up to now chiral type IIA vacua have been mostly based on intersecting D6-branes wrapping special Lagrangian 3-cycles on a CY3 manifold. We argue that there are additional BPS Dbranes which have so far been neglected, and which seem to have interesting model-building features. They are coisotropic D8-branes, in the sense of Kapustin and Orlov. The D8-branes wrap 5-dimensional submanifolds of th...
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We present some new supersymmetric solutions of massive IIA supergravity involving D0-branes, a D8-brane and a string. For the bosonic fields we use a general ansatz with SO(8) symmetry.
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2014
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1004495